The arrival of settlers and their conflicts with the natives resulted in the Yakima War. A Catholic Mission was established in Ahtanum, southwest of present-day Yakima, in 1847. In 1805, the Lewis and Clark Expedition came to the area and encountered abundant wildlife and rich soil, prompting the settlement of homesteaders. The Yakama people were the first known inhabitants of the Yakima Valley. The name Yakima originates from the Yakama Nation Native American tribe, whose reservation is located south of the city. As of 2011, the Yakima Valley produces 77% of all hops grown in the United States. It is situated in the Yakima Valley, a productive agricultural region noted for apple, wine, and hop production. Yakima is about 60 miles (100 kilometers) southeast of Mount Rainier in Washington. The unincorporated suburban areas of West Valley and Terrace Heights are considered a part of greater Yakima.

As of the 2020 census, the city had a total population of 96,968 and a metropolitan population of 256,728. Yakima ( / ˈ j æ k ɪ m ɑː/ or / ˈ j æ k ɪ m ə/) is a city in, and the county seat of, Yakima County, Washington, United States, and the state's 11th most populous city.

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